Quinolines and derivatives
Medchemexpress LLC Rivastigmine (tartrate) | 129101-54-8 | MFCD03700731 | 99.03% | 400.42 | 50 MG
Rivastigmine tartrate is an orally active and potent cholinesterase (ChE) inhibitor. It inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). This compound can pass the blood-brain barrier (BBB) and is used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
- Orally active and potent cholinesterase (ChE) inhibitor
- Inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)
- Can pass the blood-brain barrier (BBB)
- Used for research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease
- Reduces LPS-induced TNF-α and IL-6 in vitro
- Improved behavioral impairments caused by Aluminum in male Wistar albino rats
- Reduced IL-6 concentration in BALB/c OlaHsd male mice with acute colitis
Medchemexpress LLC SPP-86 | 1357349-91-7 | 99.9% | 277.32 | 100 MG
SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. It inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, and also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM.
- Inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling.
- Inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
- Click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
Medchemexpress LLC Sulfo-cyanine3 azide (potassium) | 95.3% | 736.94 | 1 MG
Sulfo-cyanine3 azide potassium is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). It can be used for synthesis of fused tricyclic heterocycles, producing immunostimulatory agents. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups, or ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm).
- Used for synthesis of fused tricyclic heterocycles, producing immunostimulatory agents.
- Contains an azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups.
- Undergoes ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
![Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000436072-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG
Guanidinoethyl sulfonate (Standard) is an analytical standard and an orally available, blood-brain permeable competitive inhibitor of taurine transporters. It acts as a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM) and shows weak agonist/antagonist effects on GABAA receptors. It inhibits taurine transmembrane transport, blocks glycine-mediated chloride influx, and may regulate brain pH for neuroprotective effects, useful in studies of ischemic brain injury. It is applied in qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.
- Analytical standard for research
- Orally available and blood-brain permeable
- Inhibits taurine transporters
- Antagonizes glycine receptors
- Modulates GABAA receptors
- Blocks glycine-mediated chloride influx
- May offer neuroprotective effects
- Used in HPLC, GC, and MS applications
Medchemexpress LLC Verteporfin | 129497-78-5 | 98.2% | 200 MG
Verteporfin (CL 318952) is a photosensitizer used in photodynamic therapy to eliminate abnormal blood vessels in the eye, especially those associated with age-related macular degeneration. It functions as a YAP inhibitor by disrupting YAP-TEAD interactions, inducing cell apoptosis. This compound also acts as an autophagy inhibitor, blocking autophagosome formation at an early stage.
- Acts as a YAP inhibitor, disrupting YAP-TEAD interactions.
- Induces cell apoptosis.
- Inhibits autophagy by blocking autophagosome formation at an early stage.
- Utilized as a photosensitizer for photodynamic therapy.
- Shows light-independent anti-leukemic activity.
- Reduces mitochondrial membrane potential in PDX cells.
- Reverses certain drug resistances by inhibiting YAP expression.
Medchemexpress LLC Apalutamide | 956104-40-8 | 99.9% | 477.43 | 200 MG
Apalutamide is a potent and competitive antagonist of the androgen receptor (AR), binding to it with an IC50 of 16 nM. It is intended for research use.
- Exhibits low micromolar affinity (IC50 3 μM) for the GABAA receptor, potentially antagonizing GABAA at therapeutic dose levels.
- Targets the AR ligand-binding domain, preventing AR nuclear translocation, DNA binding, and transcription of AR gene targets.
- Shows low systemic clearance, high oral bioavailability, and a long plasma half-life in both mouse and dog, supporting once-daily oral dosing.
- Achieves increased steady-state plasma levels in repeat-dose studies, resulting in high C24hr levels and low peak:trough ratios (2.5).
- Demonstrated significant tumor-volume reduction in castrate male mice bearing LNCaP/AR xenograft tumors.
Medchemexpress LLC 1-Piperazineacetamide, N-(2,6-dimethylphenyl)- | 5294-61-1 | 99.8% | 247.34 | 200 MG
CVT-2738 is an orally active metabolite of Ranolazine. It demonstrates a protective effect against Isoprenaline-induced myocardial ischemia in mice and is suitable for use in myocardial ischemia research.
- Orally active metabolite
- Demonstrates protective effect against myocardial ischemia
- Suitable for myocardial ischemia research
- Ships at room temperature
- Stable as powder for 3 years at -20°C
- Soluble in DMSO (10 mg/mL)
Medchemexpress LLC Valbenazine | 1025504-45-3 | 98.6% | 418.57 | 200 MG
Valbenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki of 110-190 nM. It exhibits VMAT2 binding affinity in rat striatum and human platelets. In vivo, Valbenazine induces ptosis and increases plasma prolactin in rats.
- VMAT2 inhibitor.
- Exhibits VMAT2 binding affinity in rat striatum and human platelets.
- Induces ptosis and increases plasma prolactin in rats.
- Available in solid and solution forms.
- Can be stored long-term as powder at -20°C (3 years) or 4°C (2 years).
- In solvent, stock solutions can be stored at -80°C (2 years) or -20°C (1 year).
TARGETMOL CHEMICALS INC LY2940094 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective selective and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). purity: 99%
TARGETMOL CHEMICALS INC Levosimendan 200MG
Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan exerts its effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner. Purity 99.7%
Medchemexpress LLC Sapitinib | 848942-61-0 | 200 MG
Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor with IC50s of 4, 3, and 4 nM for EGFR, ErbB2, and ErbB3 in cells, respectively. It demonstrates potent inhibitory effects on erbB2 in ligand-independent MCF-7 cl24 cells, significantly inhibits Akt phosphorylation, and induces apoptosis in human IBC cells.
- Reversible, ATP competitive EGFR inhibitor
- Potent inhibitory effect on erbB2 in ligand-independent MCF-7 cl24 cells
- Significantly inhibits phosphorylation of Akt in SUM149 and FC-IBC-02 cells
- Inhibits proliferation and induces apoptosis in human IBC cells
- Active in xenograft tumor models responsive to EGFR inhibition alone or EGFR or erbB2 inhibition
- Causes pharmacodynamic changes in proliferation and apoptosis markers in human tumor xenograft models
- Favorable oral pharmacokinetics in rat and dog
- Low human hepatocyte turnover
Medchemexpress LLC 4h-1-Benzopyran-4-one, 6-[3-(4-morpholinyl)propyl]-2-thieno[3,2-c]pyridin-6-yl-, oxime, hydrochloride | 2133294-96-7 | 98.6% | 457.97 | 25 MG
Foliglurax monohydrochloride is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM. It exhibits an antiparkinsonian effect and is for research use only.
- Highly selective and potent mGluR4 PAM.
- Brain-penetrant.
- Exhibits an antiparkinsonian effect.
- For research use only.
- Potentially revolutionizing mGlu4 receptor drug targeting in CNS disorders.
Medchemexpress LLC Liproxstatin-1 | 950455-15-9 | 99.70% | 200 MG
Liproxstatin-1 is identified as a potent ferroptosis inhibitor, effectively suppressing ferroptotic cell death with an IC50 value of 22 nM. It demonstrates anti-ferroptotic activity across various cell types, including fibroblasts, lymphocytes, and mouse embryonic fibroblasts (MEFs). Studies have also indicated its ability to suppress ferroptosis in vivo, specifically in human cells, Gpx4 deficient kidney cells, and in an ischemia/reperfusion-induced tissue injury model.
- Potent ferroptosis inhibitor.
- Inhibits ferroptotic cell death with an IC50 of 22 nM.
- Shows anti-ferroptotic activity in mouse embryonic fibroblasts with an IC50 of approximately 38 nM.
- Suppresses ferroptosis in human cells.
- Suppresses ferroptosis in Gpx4 deficient kidney.
- Suppresses ferroptosis in an ischemia/reperfusion-induced tissue injury model.
Ambeed Methyl 5bromo6oxo1 6dihydropyr
Methyl 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylate, 178876-86-3, 98%
Apexbio Technology LLC Coenzyme Q10 303-98-0 200mg
Coenzyme Q10 (CAS 303-98-0) is a lipophilic benzoquinone involved in mitochondrial electron transport and cellular energy production It functions as an essential electron carrier within the electron transport chain facilitating ATP synthesis and exhibiting antioxidant properties by mitigating oxidative damage Coenzyme Q10 is frequently studied for its role in cellular metabolism bioenergetics and redox homeostasis Due to its involvement in mitochondrial function it is widely applied in research on metabolic disorders neurodegeneration and cardiovascular diseases The compound is soluble in organic solvents such as chloroform benzene and carbon tetrachloride For optimal stability it should be stored sealed in cool and dry conditions